030 IRF7 and IRF8 have distinct effects on the pathogenesis of systemic lupus erythematosus

Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus

The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...

Pathogenesis of systemic lupus erythematosus.

The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo-pituitary-adrenal axis modifies this susceptibility and the clinical express...

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

Systemic Lupus Erythematosus: Pathogenesis and Clinical Features

Use the epidemiology and natural history of • systemic lupus erythematosus (SLE) to inform diagnostic and therapeutic decisions Describe and explain the key events in the • pathogenesis of SLE and critically analyse the contribution of genetics, epigenetics, hormonal, and environmental factors to the immune aberrancies found in the disease Explain the key symptoms and signs of the • diseases...

Poorly understood pathogenesis of Systemic Lupus Erythematosus